Synapse Evolution with Dr. Seth Grant (BSP 51)

Episode 51 of the Brain Science Podcast is an interview with Dr. Seth Grant from Cambridge University, UK.  Dr. Grant's work focuses on the proteins that make up the receptors within synapses. (Synapses are the key structures by which neurons send and receive signals.) By comparing the proteins that are present in the synapses in different species Dr. Grant has come to some surprising conclusions about the evolution of the synapse and the evolution of the brain. (Read more...)

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Dr. Brenda Milner: Pioneer of Memory Research (BSP 49)

Brain Science Podcast #49 is an interview with pioneering neuroscientist, Brenda Milner, PhD. Dr. Milner is known for her contributions to understanding memory and her work with split-brain patients. Her work as an experimental psychologist has been fundamental to the emergence of the field of cognitive neuroscience. This interview is a follow-up of Dr. Milner's recent interview with Dr. Marc Pelletier on Futures in Biotech. I highly recommend listening to both interviews.

Listen to Episode 49 of the Brain Science Podcast

Listen to Dr. Milner on Futures in Biotech (Episode33)

Click here for detailed show notes and links.

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Our "Big Brain" with Dr. Gary Lynch (BSP 48)

Episode 48 of the Brain Science Podcast is an interview with Gary Lynch, PhD, co-author of Big Brain: The Origins and Future of Human Intelligence. While it is generally agreed that one of the most striking features of the human brain is its large size, not everyone agrees about how and why our brains came to be so large. In this interview Dr. Lynch presents some rather radical theories about how the human brain evolved. We discuss the pros and cons of his theories as well as the challenges faced by researchers trying to work in this field.

Listen to Episode 48

Visit the Brain Science Podcast website for detailed Show Notes and Links.

The next episode of the Brain Science Podcast will be an interview with Dr. Brenda Milner. This interview will is a follow-up to Marc Pelletier's excellent interview of Dr. Milner on Futures in Biotech: http://www.twit.tv/fib33.

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Recorded LIVE at Dragon*Con 2008 (BSP 46)

Dragon*Con 2008 Dragon*Con 2008 Brain Science Podcast #46 is a discussion of brain imaging with Dr. Shella Keilholz and Dr. Jason Schneiderman. The focus of our discussion is functional magnetic resonance imaging (fMRI), which is revolutionizing neuroscience. We talked about both the strengths and weaknesses of this technique. Both of my guests agree that mainstream coverage of this technique tends to exagerate what we can actually tell from this kind of brain scan. An important principle is that the scan of any single individual can vary greatly from day-to-day, which means that valid conclusions require data from a large number of people.

Listen to Episode 46 of the Brain Science Podcast

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Send email feedback to Ginger Campbell, MD at docartemis at gmail.com

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Attention Deficit Disorder with Dr. John Ratey (BSP 45)

Have you ever wondered why a child with ADD can play videos games for hours but can’t concentrate on his homework for a few minutes? This is one of the paradoxes of attention-deficit disorder that  John J Ratey, MD, co-author of Driven To Distraction : Recognizing and Coping with Attention Deficit Disorder from Childhood Through Adulthood, explains in Episode 45 of the Brain Science Podcast. During this interview Dr. Ratey discusses the latest findings about the biological basis of what he calls “attention variability disorder.” He also offers practical advice for patients and parents dealing with ADD/ADHD. One very important, and somewhat surprising, fact that he shares is that patients who are treated with medications during adolescence have a significantly lower risk of developing problems with addiction and drug abuse later on compared to those who are not treated. Also, successful “ADDers” like Michael Phelps show that “having a mission” makes a huge difference. Dr. Ratey’s most recent book is Spark: The Revolutionary New Science of Exercise and the Brain, which he discussed with me (Dr. Campbell) in Episode 33.

Listen to Episode 45 of the Brain Science Podcast

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Daniel Siegel, MD on Meditation and the Brain (BSP 44)

Daniel Siegel, MD In Episode 44 of the Brain Science Podcast I talk with Daniel Siegel, MD about meditation and the brain. Dr. Siegel is the author of several books including The Mindful Brain: Reflection and Attunement in the Cultivation of Well-Being. In this interview we review the scientific evidence about how mindfulness meditation changes the brain, both in terms of short term activity and in terms of long-term structural changes. The evidence is convincing that a regular mindfulness practice can be an important element of brain health.

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Part 2 of "On Being Certain" with Robert Burton, MD (BSP 43)

Episode 43 of the Brain Science Podcast is an interview with Robert A Burton, MD, author of On Being Certain: Believing You Are Right Even When You're Not, which I discussed in Episode 42. Dr. Burton tells us what inspired him to write this book and we explore some of the implications of the fact that what he calls the "feeling of knowing" comes from our unconscious, including the fact that it is not as reliable as it feels.

Listen to Episode 43 of the Brain Science Podcast

Show Notes and Links

Robert A Burton, MD

Previous Episodes of the Brain Science Podcast:
  • Episode 42: Part 1 of our discussion of On Being Certain
  • Episode 13: Unconscious Decisions-featuring Blink by Malcom Gladwell
  • Episode 15: Interview with Read Montague about unconscious decisions
Other scientists/writers mentioned in this episode: Other terms mentioned in the interview: Cotard's Syndrome: when the patient believes they do not exist or that they are dead cognitive dissonance: a mismatch between what one believes and what the evidence supports

Listen to Episode 43 of the Brain Science Podcast

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Review: "On Being Certain" (BSP 42)

Episode 42 of the Brain Science Podcast is a discussion of On Being Certain: Believing You Are Right Even When You're Not by Robert Burton, MD. This part 1 of a two part discussion of the unconscious origins of what Dr. Burton calls "the feeling of knowing." In Episode 43 I will interview Dr. Burton. Today's episode provides an overview of Dr. Burton's key ideas. In past episodes I have discussed the role of unconscious decision-making. On Being Certain: Believing You Are Right Even When You're Not by Robert Burton, MD takes this topic to a new level. First, Dr. Burton discusses the evidence that the "feeling of knowing" arises from parts of our brain that we can neither access or control. Then he discusses the implications of this finding, including the fact that it challenges long-held assumptions about the possibility of purely rational thought.

Listen to Episode 42 of the Brain Science Podcast

References and Links:

On Being Certain: Believing You Are Right Even When You're Not by Robert Burton, MD

Neisser, U., and Harsh, N. "Phantom Flashbulbs: False Recollections of Hearing the News about Challenger,"  in Affect and Accuracy in Recall: Studies of "Flashbulb" Memories, Winograd, E., and Neisser, U., (New York: Cambridge University Press, 1992)

The Seven Sins of Memory: How the Mind Forgets and Remembers by Daniel L. Schacter

The Feeling of What Happens: Body and Emotion in the Making of Consciousness by Antonio Damasio

Philosophy in the Flesh : The Embodied Mind and Its Challenge to Western Thought by George Lakoff and Mark Johnson

Other Scientists Mentioned in this Episode:

  • Leon Festinger-proposed the theory of cognitive dissonance in 1957
  • Joseph Ledoux-research with rats and the role of the amygdala in the fear response
  • Michael Merzenich-showed how the auditory cortex in young rats is affected by experience

Listen to Episode 42 of the Brain Science Podcast

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Interview with Linguist Alice Gaby (BSP 41)

Episode 41 of the Brain Science Podcast is an interview with Alice Gaby, PhD, from the University of California-Berkeley. Dr. Gaby is a linguist who studies the role of language in cognition as well as the aboriginal languages of Australia. In this episode Dr. Gaby introduces some of the basic areas of linguistics. We also talk about why linguistics is important to understanding brain function, as well as the importance of interdisciplinary communication to advancement in both fields. Dr. Gaby's infectious enthusiasm makes this potentially intimidating subject accessible to everyone.

Listen to Episode 41 of the Brain Science Podcast

Visit the Brain Science Podcast website for more information, including detailed show notes and links.

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Third Semi-annual Review Episode (BSP 40)

Episode 40 of the Brain Science Podcast is a look back at the highlights from the last six months. We have talked about numerous topics including brain plasticity, mirror neurons, language, brain rhythms, and the sense of smell. We talked with 9 guests and we have also explored the practical implications of neuroscience, including the importance of sleep and exercise to brain health. This brief review episode is intended for both new listeners and long-time subscribers.

Listen to Episode 40

For detailed show notes including links to all the resources discussed in the episode

please visit the Brain Science Podcast website

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Michael Arbib on Mirror Neurons (BSP 39)

Episode 39 of the Brain Science Podcast is an interview with Dr. Michael Arbib from the University of Southern California. Dr. Arbib's work with functional brain imaging has established the presence of mirror neurons in the human brain. In our interview we focused on the role of mirror neurons in imitation and language. In particular I questioned Dr. Arbib about the Mirror System Hypothesis (MSH) of Language Evolution that he proposed in 1998 with Giacomo Rizzolatti. We also explored how this hypothesis diverges from the universal grammar proposed by Noam Chomsky. Dr. Arbib also shared his enthusiasm for future research and we talked about the special challenges caused by the interdisciplinary nature of modern neuroscience.

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Related Episodes:

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Interview with Jeff Hawkins "On Intelligence" (BSP 38)

Jeff Hawkins Episode 38 of the Brain Science Podcast is an interview with Jeff Hawkins, author of On Intelligence. Hawkins is well-known for founding Palm Computing and Handspring. He invented the Grafitti handwriting recognition system and helped develop the Palm Trio SmartPhone. Since he published his bestseller On Intelligence, he has devoted his work to his passion for neuroscience. His current company Numenta is developing software that models the hierarchal structure of the neocortex. In this interview we talk about the ideas in Hawkins book and how he is applying them to develop a computer model of cortical function. This is a follow-up to Episode 2, which first aired in December of 2006.

Listen to Dr. Campbell interview Jeff Hawkins.

Links and References:

Jeff Hawkins: wikipedia entry Vernon Montcastle: pioneer who proposed that all parts of the brain's cortex work the same way.
  • Vernon Mountcastle (1978), "An Organizing Principle for Cerebral Function: The Unit Model and the Distributed System", The Mindful Brain (Gerald M. Edelman and Vernon B. Mountcastle, eds.) Cambridge, MA: MIT Press (Please let me know if you find this paper on-line!)
  • Perceptual Neuroscience: The Cerebral Cortex by Vernon B. Mountcastle. This 1998 is recommended by Jeff Hawkins, especially for those interested in the technical details of cortical function.
Redwood Institute for Theoretical Neuroscience (UC-Berkeley) founded by Jeff Hawkins Numenta: company website includes extensive educational information about hierarchical temporal memory system (HTM). The company's focus is practical implementation of HTM Theory.

Listen to Episode 38

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"Brain Rules" with Dr. John Medina (BSP 37)

John Medina, PhD Episode 37 of the Brain Science Podcast is an interview with Dr. John Medina, author of Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School. We talk about how exercise, sleep, and stress effect our brains with an emphasis on practical advice for healthier brain function. We also look at how research on memory, vision and the brain's attention system suggests how we can improve our ability to learn and our ability to share ideas with others. Dr. Medina's focus is on considering real world examples of how our schools and work environments could be reformed to utilize the growing knowledge of neuroscience. But he also stresses the importance of compiling sufficient experimental data before embarking on new programs.

Listen to Episode 37 now (left click to listen, right click to download mp3).

Links and References: Brain Rules: 12 Principles for Surviving and Thriving at Work, Home, and School (Book & DVD) by John Medina The book's website contain extensive references and instructive videos. YouTube Video of John Medina speaking at Google™.

Listen to Brain Science Podcast #37

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Art Glenberg discusses Embodied Cognition (BSP 36)

Art Glenberg, PhD Episode 36 of the Brain Science Podcast is an interview with Arthur Glenberg, PhD about embodied cognition. Dr. Glenberg recently moved to Arizona State University after over 30 years at the University of Wisconsin's Laboratory of Embodied Cognition. His research focuses on the relationship between embodiment and language. In this interview we explore the experimental evidence for a theory of language that embraces the concept that our language abilities are actually rooted in our perceptual and motor abilities. Dr. Glenberg also explains how his work has practical implications in helping children learn how to read. Since Dr. Glenberg has had a long career as a working research scientist, this interview also provided an opportunity to explore how scientific hypotheses are formed and how experiments are designed to test these hypothesis. I think this interview will give you a fascinating look into the real world of cognitive psychology.

Listen to Dr. Glenberg's Interview (left click to listen, right click to download)

Links and References: Arthur Glenberg, PhD Other Scientists Mentioned in the Episode:
  • George Lakoff: pioneering linguist
  • James Gibson-known for his ideas about affordances
  • William Epstein-emeritus professor at the University of Wisconsin
  • Joseph Campos: University of California (Berkelely)
  • Amy Needham and Amanda Woodard-experiments with velcro mits and infant cognition
  • David A Havas: graduate student and co-author with Dr. Glenberg
  • Mike Kashak: Florida State University
  • Mike Rinck: German co-author-see paper under Glenberg (more papers)
  • Vittorio Gallese, Dept of Neuroscience, University of Parma, Italy (where mirror neurons were discovered): extensive experimental with motor neurons in monkeys
  • Fritz Stack (Germany): experiments showing that facial experiments affect mood and cognition
References: Listen to Dr. Glenberg's Interview (left click to listen, right click to download)

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Mirror Neurons (BSP 35)

Mirrors in the Brain Brain Science Podcast #35 is a discussion of Mirrors in the brain: How our minds share actions, emotions, and experience by Giacomo Rizzolatti and Corrado Sinigaglia. Mirror neurons were discovered in Rizzolatti's lab in Parma Italy in the early 1990's and his book is a detailed to discussion of the experimental evidence in both monkeys and humans. Direct single neuron recordings have been made in monkeys. The evidence in humans is indirect since it is based on mainly on neuroimaging studies like PET scans and fMRI scans. Even so mirror neurons appear to be essential to our ability to understand both the actions and emotions of others. Listen Now. In this episode we also explore the evidence that there are other neurons in the motor areas of the brain that have sensory properties and that the areas of the brain traditionally thought to be devoted to sensory functions also contain neurons with motor properties. Another fascinating discovery is the fact that there are neurons that respond not only to somatosensory inputs (such as being touched) but also to visual or auditory inputs from objects within our peri-personal space. For background on these body maps I recommend listening to Episode 21 and Episode 23. If you are new to the Brain Science Podcast you may want to listen to those episodes first because this week's episode is a little more technical than most. I will be exploring the importance of these discoveries in future episodes.

Listen to Brain Science Podcast Episode 35 (mirror neurons) NOW.

Links: Giacomo Rizzolatti- University of Parma Mirror neurons (wikipedia entry) Mirror neurons (Scholarpedia entry written by Dr. Rizzolatti)

Listen to Brain Science Podcast #35 (mirror neurons) Now

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Rachel Herz talks about Smell (BSP 34)

rachelherz.jpgRachel Herz Episode 34 of the Brain Science Podcast is an interview with Rachel Herz author of The Scent of Desire: Discovering Our Enigmatic Sense of Smell (2007). Dr. Herz teaches at Brown University and she is a leading authority on the psychology of smell. We talk about the how smell works, its role in emotion and memory, why it is so vulnerable, and why smell is much more important than most of us realize. We also consider some of the questions that remain unanswered. Listen to the Rachel Herz interview now. (Right click to download.) Links and References: Rachel Herz The 2004 Nobel Prize for Medicine and Physiology was awarded to Richard Axel and Linda B. Buck for their discoveries of "odorant receptors and the organization of the olfactory system." BuckL, Axel R "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition." Cell. 1991 Apr 5;65(1):175-87. "The (Shocked) Nose Knows" by Gisela Telis ScienceNOW Daily News 27 March 2008 scentofdesire.jpgThe Scent of Desire: Discovering Our Enigmatic Sense of Smell (2007) by Rachel Herz Listen to Episode 34 (Right click to download) Share your comments on the Discussion Forum Audience Survey itunes-chicklet.gif Subscribe via iTunes™ Subscribe in a reader or podcatcher Subscribe to Brain Science Podcast with Dr. Ginger Campbell by Email Donations and Subscriptions are appreciated

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Exercise and the Brain (BSP 33)

Episode 33 of the Brain Science Podcast is an interview with Harvard physician, Dr. John Ratey about his new book Spark: The Revolutionary New Science of Exercise and the Brain. johnpic_profile.jpgJohn J Ratey, MD We explore the exciting evidence about how exercise helps the brain. It stimulates the release of a number of different neurotransmitters and neuropeptides, but probably more importantly it helps keeps these compounds balanced. We consider why exercise is so important in dealing with stress, in treating a wide range of mental illnesses including depression, anxiety, and attention deficit disorder. There is also evidence that exercise improves our ability to learn and our ability to avoid the loss of mental agility associated with aging. Listen to Episode 33 Now. This episode contains information that everyone can use. I hope you will share it with your friends and family. Links and References: spark-ratey.jpgSpark: The Revolutionary New Science of Exercise and the Brain (2008) by John J. Ratey Dr. Ratey's website: Go here for more interview of Dr. Ratey and also to find links to the latest research about exercise and the brain. Listen to Dr. Ratey's Interview Now. Share your comments on the Discussion Forum Audience Survey itunes-chicklet.gif Subscribe via iTunes™ Subscribe in a reader or podcatcher Subscribe to Brain Science Podcast with Dr. Ginger Campbell by Email

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Illustrations and Enhanced Versions for BSP 32

mri200.jpgEpisode 32 of the Brain Science Podcast was a whirlwind tour of brain anatomy based on Beyond the Zonules of Zinn: A Fantastic Journey Through Your Brain (2008) by David Bainbridge. The author has graciously share the illustrations from his book and I have posted a special page that is keyed to the podcast. I have also created an http://media.libsyn.com/media/brainsciencepodcast/32-enhanced-brainscience-anatomy.m4a, which will appear in the feed tomorrow. I think the images are best viewed on the web, but I would appreciate your feedback on both the website illustrations and the enhanced podcast. See the illustrations on the Brain Science Podcast website. View the enhanced podcast (requires Quicktime).
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